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In the the latest review, we documented the identification as well as the characterization of a completely new atypical opioid receptor with unique detrimental regulatory Qualities toward opioid peptides.1 Our effects showed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is likewise a wide